![]() Recent thymic emigrants are tolerized in the absence of inflammation. Cutting Edge: Enhanced clonal burst size corrects an otherwise defective memory response by CD8+ recent thymic emigrants. Cutting Edge: CD8+ recent thymic emigrants exhibit increased responses to low affinity ligands and improved access to peripheral sites of inflammation. Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal center interactions. Recent thymic emigrants and mature naïve T cells exhibit differential DNA methylation at key cytokine loci. Post-thymic maturation: young T cells assert their individuality. Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool. Bcl-2-interacting mediator of cell death influences autoantigen-driven deletion and TCR revision. Recent thymic emigrants are biased against the Th1 and toward the Th2 effector lineage. Current work is centered on dissecting the metabolic reprogramming that defines peripheral T cell maturation, interrogating the environmental cues (such as the inflammatory milieu) that tune this tolerance process and developing a model to test the involvement of recent thymic emigrants (including neonatal T cells) in tumor rejection. Our findings suggest the purpose of post-thymic T cell maturation is to expose young T cells to antigens expressed only outside the thymus, during a tolerance-prone transitional phase of development. ![]() Our lab has shown that T cells complete both functional and phenotypic maturation in the lymphoid periphery, a process driven by factors other than those that control T cell homeostasis and survival. Professor Of Cinematic Arts Georges Mlis Endowed Chair in Visual Effects. In 2009, the Lithuanian Academy of Sciences elected him its Foreign Member.The Fink Lab focused on the analysis of recent thymic emigrants (the youngest peripheral T cells) from mice carrying a transgene for green fluorescent protein driven by the RAG2 promoter. Shur was listed by the Institute of Scientific Information as Highly Cited Researcher. Wiley 1866 Distinguished Faculty Award, Rensselaer Outstanding Engineering Professor Award, Institute of Electronic Technology Achievement Medal, ECS Electronic and Photonics Award, Jefferson Science Fellowship, Recognition Award from iNEER, Tibbetts Award for Technology Commercialization, IEEE Sensors Council Technical Achievement Award, IEEE Donald Fink Best Paper Award, IEEE Kirchmayer Award, the Gold Medal of the Russian Education Ministry, van der Ziel Award, Senior Humboldt Award, Pioneer Award, RPI Engineering Research Award, Wiley Award, RPI Outstanding Faculty Award, and several Best Paper Awards. Petersburg Technical University and University of Vilnius Honorary Doctorates, Distinguished Faculty Naval Research Fellowships, William H. Shur is Distinguished Lecturer of IEEE EDS society. Shur is Life Fellow of IEEE, APS, ECS, and SPIE, Fellow of the National Academy of Inventors, OSA, IET, MRS, WIF, and AAAS. (a leading producer of deep ultraviolet LEDs) and founder of co-founder of several other startups, including Electronics of the Future, Inc. He was also a co-founder and Vice-President of Sensor Electronics Technology, Inc. He is Patricia and Sheldon Roberts Professor of Solid State Electronics and Professor of Physics, Applied Physics, and Astronomy at Rensselaer Polytechnic Institute and co-founder, President and CEO of Electronics of the Future, Inc. Petersburg Electrotechnical Institute, and PhD. Shur received MSEE Degree (with honors) from St.
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